Pituitary-The Pentium of the
Brain
It is about the size of a garbonzo bean measuring about 1 cm in
diameter and weighing about ½ to 1 gram and it sits in a depression
in the base of the skull called the sella turcica (Turkish saddle).
Its name is derived from Latin as in ancient times it was
thought to be the source of the glutinous mucus emanating from the
nose. This small ductless
gland rests in the middle of the skull base between the eyes and
directly behind the bridge of the nose.
It is one of three efferent (outgoing) systems that emerge from
the brain and spinal cord. Two
of these are neural (of nerves).
One of these neural systems affects our organ systems and the
other the remainder of our body.
The third efferent system is humoral---the neuroendocrine
system (hormones).
This little gland could be likened to the pentium processor of current
desktop computer systems. The
pituitary gland is employed by the neuroendocrine system to regulate
the function of many organs including the kidneys, uterus and breasts
and it supports and regulates the function of other organs that secret
hormones such as the thyroid and adrenal glands, ovaries and
testicles. The pituitary
gland affects the growth and development of our bodies as it maintains
and regulates metabolism and it plays a vital role in reproduction.
Tomes have been written about the pituitary and its physiology.
Perhaps even more has been written about the conditions
produced by disorders of the pituitary. In fact, there are few subjects in medicine as the pituitary
and its disorders that overlap upon the fields of so many specialists.
Space simply does not permit even a summary discussion of the
conditions that may arise from abnormal pituitary function.
I will limit this to pituitary tumors that usually arise from
the pituitary gland. Most pituitary tumors are benign (non-cancerous), generally
grow very slowly and do not spread to other parts of the body.
They usually become apparent due either to a hormonal
disturbance or due to the pressure they produce upon other parts of
the nervous system, namely the optic nerves.
If the optic nerves become compressed by a pituitary tumor this
may cause poor or absent peripheral vision.
Pituitary tumors may be the cause of menstrual disorders,
decreased libido (interest or desire in sex), headache, vision
impairment, growth failure, fatigue and even excessive thirst and
frequent urination. Certain
types of tumors may cause infertility, osteoporosis, gigantism,
dwarfism, impotence, marked changes in ring or shoe size, enlargement
of the hands, feet, facial features and enlargement of the tongue.
Other tumors may cause fat buildup in the face, back and chest
resulting in weight gain while the arms and legs become relatively
thin. Some patients with pituitary tumors develop mood swings or
excessive hair growth, severe stretch marks and even irregular or
rapid heart rate. If your
doctor suspects a pituitary tumor, blood tests are necessary to
determine how the tumor has affected the neuroendocrine system.
Usually a MRI of the brain is done to judge the size and
characteristics of the tumor.
Treatments
for pituitary tumors depend upon the type and size of the tumor as
well as the patient’s age and overall health.
Generally these tumors are treated by medication therapy,
radiation therapy or surgery. Many
tumors can be treated with medications alone but some require one or
more of the other types of treatment.
Remember, tumors of the pituitary gland are almost invariably
benign and are usually curable.
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